About the Project
The strategic framework FIGHT-TWO (PTDC / CVT-CVT / 29062/2017-PT2020) is the development and production of an oral and safe vaccine against RHDV2 for the wild rabbit.
This edible vaccine will be distributed in the field as bait or dry food and has the potential to protect a large proportion of the wild rabbits populations, crucial for reducing virus transmission and controlling infection, overcoming the need for capture and handling of the animals.
SUMMARY OF ACTIVITIES
Production and purification of RHDV2 VP60-VLPs; Structural and functional evaluation of VP60-VLPs.
Evaluation of the resistance of the VP60-VLPs to temperature, humidity and lyophilisation.
Testing the oral route for RHDV2-vaccine immunization of domestic and wild rabbits; Challenge with infectious virus to evaluate immunological protection conferred by the vaccine.